Publications

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2017

S. Oke, Alberto Martin* (2017) Insights into the role of the intestinal microbiota in colon cancer. Therapeutic Advances in Gastroenterology. In Press

K. Bromberg, T. Mitchell, A. Upadhyay, C. Jakob, L. Lasko, C. Li, C. Tuzon, Y. Dai, F. Li, M. Eram, A. Nuber, N. Soni, V. Manaves, M. Algire, R. Sweis, M. Torrent, G. Schotta, C. Sun, M. Michaelides, A. Shoemaker, C. Arrowsmith, P. Brown, V. Santhakumar, Alberto Martin, J. Rice, G. Chiang, M. Vedadi, D. Barsyte-Lovejoy and W. Pappano (2017) The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in the maintenance of genomic integrity. Nat Chem Biol. Vol 13, p317-324

2016

M. Le , D. Haddad , A. Ling, C. Li, C. So, A. Chopra, R. Hu, J. Angulo, J. Moffat, Alberto Martin* (2016) Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching. Scientific Reports 6:37215

S. Ramachandran, D. Haddad, C. Li, M. Le, A. Ling, C. So, R. Nepal, J. Gommerman, K. Yu, T. Ketela, J. Moffat, Alberto Martin* (2016) The SAGA deubiquitination module promotes DNA repair and class switch recombination through DNAPK-mediated gH2AX formation. Cell Reports. Vol. 15, p1554–1565

S. Li & Alberto Martin* (2016) Mismatch Repair and Colon Cancer: Mechanisms and Therapies Explored. Trends in Molecular Medicine. Vol 22, p. 274-289

2015

Irrazábal* & Alberto Martin* (2015) T regulatory cells gone bad: An oncogenic immune response against enterotoxigenic B. fragilis infection leads to colon cancer. Cancer Discovery. Vol. 5, p. 1021-1023

A. Belcheva*, T. Irrazábal, Alberto Martin* (2015) Gut microbial metabolism and colon cancer: Can manipulations of the microbiota be useful in the management of gastrointestinal health. BioEssays. Vol. 37, p. 403-12

A. Belcheva & Alberto Martin* (2015) Gut microbiota and colon cancer: the carbohydrate link. Molecular Cellular Oncology. Vol 2. p. 1-2

2014

S. Shalhout, D. Haddad, A. Sosin, AT. Holland, A. Al-Katib, Alberto Martin, A. Bhagwat (2014) Homeostasis in Genomic Uracil Creation and Elimination during Normal B Cell maturation, and loss of this balance during B Cell cancer development. Mol Cell Biol. Vol. 34, p. 4019-32.

K. Johnson-Henry, L. Pinnell, A. Waskow, T. Irrazabal, Alberto Martin, M. Hausner, P.M. Sherman(2014) Effects of a Short-Chain Fructo-oligosaccharide and Inulin in Caco2-bbe and C57Bl/6 Mice Models of Intestinal Injury. J. Nutrition. Vol. 144, p. 1725-33

F. Soares, I. Tattoli, M. Rahman, S. Robertson, A. Belcheva, D. Liu, C. Streutker, S. Winer, D. Winer, D. Arnoult, Alberto Martin, D. Philpott, S. Girardin (2014) The mitochondrial protein NLRX1 controls apoptotic cell death in cancer cells. J. Biol Chem. Vol. 289, p.19317-30.

A. Belcheva, T. Irrazabal, S. Robertson, C. Streutker, E. Moriyama, H. Maughan, S. Kumar, B. Green, S. Rubino, R. Pezo, W. Navarre, M. Milosevic, B. Wilson,  S. Girardin, W. Edelmann, T. Wolever, D. Guttman, D. Philpott, Alberto Martin*(2014) Gut microbial metabolism fuels colorectal cancer in Msh2-deficient hosts. Cell. Vol. 158, p. 288-299.

T. Irrazábal, A. Belcheva, S. Girardin, Alberto Martin* and D. Philpott*(2014) The multifaceted role of the intestinal microbiota in colon cancer. Molecular Cell. Vol. 54, p. 309-20.

2013

B. Boulianne, O. Rojas, D. Haddad, A. Zaheen, A. Kapelnikov, T. Nguyen, J. Gommerman*, Alberto Martin*  (2013) AID and Caspase 8 shape the germinal center response through apoptosis. J. Immunology. Vol. 191, p. 5840-47.

 B. Boulianne, M. Le, L. Ward, L. Meng, Alberto Martin*, J. Gommerman* (2013)Lymph Node Germinal Centers form in the absence of Follicular Dendritic Cells, but their maintenance and function requires Lymphotoxin-b Receptor signaling. J. Immunology.  Vol. 191, p. 4521-30.

A. Belcheva, B. Green, A. Weiss, C. Streutker, Alberto Martin* (2013). Elevated incidence of polyp formation in APCMin/+Msh2-/- mice is independent of nitric oxide-induced DNA mutations. PLOS One. Vol. 8(5), e65204.

G. Galicia-Rosas, B. Boulianne, N. Pikor, Alberto Martin, J. Gommerman (2013) Secondary B cell Receptor diversification is necessary for T cell mediated neuroinflammation during Experimental Autoimmune Encephalomyelitis. PLOS One. Vol. 8(4), e61478.

2012

M. Larijani* & Alberto Martin* (2012) The Biochemistry of Activation-Induced Cytidine Deaminase and its physiological functions. Seminars in Immunology. Vol. 40, p. 548-563.

H. Li, R.M. Nepal, Alberto Martin, S.A. Berger (2012). Induction of apoptosis in Eμ-myc lymphoma cells in vitro and in vivo through calpain inhibition. Expt. Hematology. Vol. 40, p. 548-563.

J. Parsa, S. Ramachandran, A. Zaheen, R. Nepal, A. Kapelnikov, A. Belcheva, M. Berru, D. Ronai, Alberto Martin* (2012). Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis. PLoS Genetics. Vol. 8, e1002518.

A. Dancyger, J. King, M. Quinlan, H. Fifield, S. Tucker, H. Saunders, M. Berru, B. Magor, Alberto Martin, M. Larijani (2012). Differences in the enzymatic efficiency of bony fish and human AID are mediated by a single residue in the C-terminus that modulates single-stranded DNA binding. FASEB J. Vol. 26, p.1517-25.

J.H. Fritz, D. McCarthy, N. Simard, O. Lucia Rojas, S. Hapfelmeier, S. Rubino, S. Robertson, M. Larijani, I. Ivanov, Alberto Martin, R. Casellas, D. Philpott, S. Girardin, K. McCoy, A. Macpherson, C. Paige and J. Gommerman (2012).Acquisition of a multifunctional TNF/iNOS-producing IgA+ plasma cell phenotype in the gut. Nature. Vol. 481, p.199-203.

2011

B. Green, A, Belcheva, R.M. Nepal, B. Boulianne, and A. Martin (2011)The mismatch repair pathway functions normally at a non-AID target in germinal center B cells. Blood. Vol. 118, p. 3013-8.

B. Duvvuri, V. Duvvuri, J. Grigull, A. Martin, Q. PanHammarstrom, G.E. Wu, M. Larijani (2011). Altered spectrum of somatic hypermutation in Common Variable Immunodeficiency Disease characteristic of defective repair of AID-induced mutations. Immunogenetics. Vol. 63, p.1-11.

A. Zaheen and A. Martin (2011) Activation induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities. Amer. J. of Pathology. Vol. 178, p.462-71.

2010

S. Ramachandran, R. Chahwan, R.M. Nepal, D. Frieder, S. Panier, A. Zaheen, D. Durocher, M. Scharff, and A. Martin (2010). The RNF8/RNF168 ubiquitin ligase cascade is required for class switch recombination. Proc Natl Acad Sci USA.Vol. 107, p. 809-814

2009

R.M. Nepal, L. Tong, B. Kolaj, W. Edelmann, A. Martin (2009). Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-myc-induced lymphomas. Proc Natl Acad Sci USA. Vol. 106, p. 18698-703.

D. Frieder, M. Larijani, C. Collins, M. Shulman, A. Martin (2009). The concerted action of Msh2 and UNG stimulates error-prone repair at A:T basepairs in hypermutating B cells. Mol Cell Biol. Vol. 18, p. 5148-57.

A. Zaheen, B. Boulianne, S. Ramachandran, J.Y. Parsa, J.L. Gommerman, A. Martin (2009). AID constrains Germinal Center size by Rendering B cells Susceptible to Apoptosis. Blood. Vol. 114, p.547-554.

2008

R.M. Nepal, A. Zaheen, W. Basit, L. Li, S.A. Berger, A. Martin (2008). AID and RAG1 do not contribute to lymphomagenesis in Em c-myc transgenic mice. Oncogene. Vol. 27, p.4752-6.

2007

S.A. Lee, J.Y. Parsa, A. Martin, M.D. Baker(2007). Preferential integration of plasmid DNA into the immunoglobulin switch m region in hybridoma cells expressing activation-induced cytidine deaminase. Eur J Immunol. Vol. 37, p. 3529-39

M. Larijani, A. Martin (2007). ssDNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID. Mol Cell Biol. Vol. 27, p. 8038-48.

D. Ronai, M.D. Iglesias-Ussel, M. Fan, Z. Li, A. Martin, M.D. Scharff(2007) Detection of Chromatin-Associated ssDNA in Regions Targeted for Somatic Hypermutation. J. Exp. Med. Vol. 204, p.181-190.

E.S. Tang, A. Martin. (2007) Immunoglobulin Gene Conversion: Synthesizing antibody diversification and DNA repair. DNA Repair. Vol. 6, p. 1557-71.

M. Larijani, A. Petrov, O. Kolenchenko, M. Berru, S. Krylov and A. Martin (2007). AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner. Mol Cell Biol. Vol. 27, p.20-30.

J.Y. Parsa, W. Basit, C.L. Wang, J.L. Gommerman, J.R. Carlyle, A. Martin (2007)AID mutates a non-immunoglobulin transgene independent of chromosomal position. Mol Immunol. Vol. 44 p. 567-75.

2006

E.S. Tang, A. Martin. (2006) NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: Evidence for a double strand break intermediate. Nucleic Acids Research. Vol. 34, p.6345-51.

D. Frieder, M. Larijani, E. Tang, J. Parsa, W. Basit, A. Martin (2006) Antibody diversification: mutational mechanisms and oncogenesis. Immunologic Research. Vol. 35, p.75-88.

2005

M. Larijani, A. Zaheen, D. Frieder, Y. Wang, G.E. Wu, W. Edelmann, A. Martin (2005) Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events.Nucleic Acids Research. Vol. 33, p. 6733-6742.

M. Larijani, D. Frieder,W. Basit, A. Martin (2005) The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung-/-msh2-/- mice. Immunogenetics. Vol. 56, p.840-5.

M. Larijani, D. Frieder, T. Sonbuchner, R. Bransteitter, M. Goodman, E. Bouhassira, M. Scharff, A. Martin (2005) Methylation protects cytidines from AID-mediated deamination. Mol Immunol. Vol. 42, p.599-604.

2004

Z. Li, S. Scherer, D. Ronai, M. Iglesias, J. Peled, P. Bardwell, M. Zhuang, K. Lee, A. Martin , W. Edelmann, M. Scharff (2004). Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinctive roles of MutS homologues in antibody diversification. J. Exp. Med. Vol. 200, p.47-59.

2003

P. Bardwell, C. Woo, K. Wei, Z. Li, A. Martin , S. Sack, W. Edelmann, M Scharff (2003). Altered somatic hypermutation and reduced class switch recombination in Exonuclease 1-mutant mice.  Nat. Immunology. Vol. 5, p. 224-229.

A. Martin , Z. Li, D Lin, P. Bardwell, M. Iglesias, W. Edelmann, M. Scharff (2003). ATPase activity of Msh2 is essential for somatic hypermutation at A-T basepairs and for efficient class switch recombination. J. Exp. Med. Vol. 200, p.47-59.

C. Woo, A. Martin , M. Scharff (2003). Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity. Vol. 19, p. 479-489.

P. Bardwell, A. Martin , E. Wong, Z. Li, W. Edelmann, M. Scharff (2003). The G-U mismatch glycosylase Mbd4 is dispensable for somatic hypermutation and class switch recombination. J. Immunol. Cutting Edge. Vol. 170, p. 1620.

2002

A. Martin and M. Scharff (2002) Somatic hypermutation of the AID transgene in B and non-B cells.Proc Natl Acad SciUSA . Vol. 99, p. 12304.

P. Bardwell, A. Martin , M. Scharff (2002) Mutation detection of immunoglobulin V-regions by DHPLC. J. Immunol. Meth., Vol. 266, p. 165.

A. Martin and M. Scharff (2002) AID and mismatch repair in antibody diversification. Nat. Rev. Immunol., Vol. 2, p. 605.

A. Martin , P. Bardwell, C. Woo, M. Fan, M. Shulman, M. Scharff (2002) Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature, Vol. 415, p. 802-806.

2001

A. Martin and M. Scharff (2001) Antibody Alterations (News and Views). Nature, Vol. 412, p. 870-871.

W. Zhang, P. Bardwell. C. Woo, V. Poltoratsky, M. Scharff, A. Martin (2001). Clonal instability of V-region hypermutation in the Ramos Burkitt’s lymphoma cell line. Internat. Immunol., Vol. 13, p. 1175-1184.

V. Poltoratsky, C Woo, B. Tippin, A. Martin , M Goodman, M Scharff (2001) Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proc Natl Acad Sci USA, Vol. 98, p.7976-7981.

 

* Corresponding author